منابع مشابه
Vpr makes holes
and colleagues. The holes allow the mixing of proteins that are usually exclusively nuclear or cytoplasmic. The damage, the mixing, or both may cause a G2 cell cycle arrest that allows the virus to replicate more efficiently. For some time Greene has been studying the ability of Vpr to arrest the cell cycle. Vpr shuttles into the nucleus, so Greene suspected that it could affect the shuttling o...
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The T-Vpack and VPR toolset [6, 7] have been widely used to perform FPGA CAD and architecture research, but have not evolved over the past decade to include many architectural features now present in modern FPGAs. This paper describes a new version of the toolset that includes four significant features: The router now supports a broad range of single-driver routing architectures [29, 4, 16] whi...
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The human immunodeficiency virus 1 (HIV-1) viral protein R (Vpr) is an accessory protein that has been shown to have multiple roles in HIV-1 pathogenesis. By screening chemical libraries in the RIKEN Natural Products Depository, we identified a 3-phenyl coumarin-based compound that inhibited the cell cycle arrest activity of Vpr in yeast and Vpr-dependent viral infection of human macrophages. W...
متن کاملYeast perspectives on HIV-1 VPR.
Increasing evidence suggests that HIV-1 viral protein R (Vpr) plays an important role in viral pathogenesis, as its functions are being linked to viral activation, suppression of human immune functions and depletion of human CD4 lymphocytes, which are the major clinical manifestation of AIDS. In vitro, Vpr shows multiple activities both in mammalian and yeast cells, which include nuclear transp...
متن کاملHIV-1 Vpr—a still “enigmatic multitasker”
Like other HIV-1 auxiliary proteins, Vpr is conserved within all the human (HIV-1, HIV-2) and simian (SIV) immunodeficiency viruses. However, Vpr and homologous HIV-2, and SIV Vpx are the only viral auxiliary proteins specifically incorporated into virus particles through direct interaction with the Gag precursor, indicating that this presence in the core of the mature virions is mainly require...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2001
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1555rr2